Nuclear magnetic resonance: a key metabolomics platform in the drug discovery process. (June 2015)

• Record Type: Journal Article
• Authors: Leenders, Justine; Frédérich, Michel; de Tullio, Pascal
• Is Part Of: Drug discovery today. Volume 13(2015)
• Page Start: 39
• Page End: 46
• Publication Date: 2015-06
• Subjects: Drug development -- Periodicals; Physiology, Pathological -- Periodicals; Drugs -- Design -- Periodicals; 615.1
• DOI: 10.1016/j.ddtec.2015.06.005
• Languages: English
• ISSNs: 1740-6749

Abstract

Abstract : Metabolomics is an innovative tool that is now emerging in the drug discovery process. Indeed, its ability to follow the dynamic perturbations in the metabolome resulting from pathologies but also from drug treatment and or/toxicity is of value for the development of new therapeutic approaches. Nuclear magnetic resonance (NMR) spectroscopy, which is an important analytical technique for several steps of the lead discovery, validation and optimization processes, has been described, together with mass spectrometry (MS) as one of the major platform that could be used for metabolomics studies. This review highlights why NMR could be considered a key tool for the application of metabolomics in drug discovery.