Chemical probes for methyl lysine reader domains. (August 2016)

• Record Type: Journal Article
• Authors: James, Lindsey I; Frye, Stephen V
• Is Part Of: Current opinion in chemical biology. Volume 33(2016)
• Page Start: 135
• Page End: 141
• Publication Date: 2016-08
• Subjects: Bioorganic chemistry -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Clinical biochemistry -- Periodicals; Biochemistry -- Periodicals; Chimie bio-organique -- Périodiques; Biologie -- Périodiques; 572.05
• DOI: 10.1016/j.cbpa.2016.06.004
• Languages: English
• ISSNs: 1367-5931

Abstract

Abstract : The primary intent of a chemical probe is to establish the relationship between a molecular target, usually a protein whose function is modulated by the probe, and the biological consequences of that modulation. In order to fulfill this purpose, a chemical probe must be profiled for selectivity, mechanism of action, and cellular activity, as the cell is the minimal system in which 'biology' can be explored. This review provides a brief overview of progress towards chemical probes for methyl lysine reader domains with a focus on recent progress targeting chromodomains.