Bio-mediated oxidative resolution of racemic 2-substituted 1, 2, 3, 4-tetrahydroquinolines. Issue 22 (1st June 2016)

• Record Type: Journal Article
• Authors: Qin, Lei; Zheng, Daijun; Cui, Baodong; Wan, Nanwei; Zhou, Xiaojian; Chen, Yongzheng
• Is Part Of: Tetrahedron letters. Volume 57:Issue 22(2016)
• Page Start: 2403
• Page End: 2405
• Publication Date: 2016-06-01
• Subjects: Biocatalysis -- Whole cell -- Pseudomonas monteilii -- Oxidative resolution -- 2-Substituted 1, 2, 3, 4-tetrahydroquinolines; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.04.066
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A new function of Pseudomonas monteilii strain was found. Asymmetric resolution of 2-substituted 1, 2, 3, 4-tetrahydroquinolines was developed. 8 highly enantioselective 2-substituted 1, 2, 3, 4-tetrahydroquinolines were obtained. Abstract: Whole cell of Pseudomonas monteilii ZMU-T01 strains mediated oxidative resolution of racemic 2-substituted 1, 2, 3, 4-tetrahydroquinolines has been successfully described. A series of highly enantioselective 2-substituted 1, 2, 3, 4-tetrahydroquinoline derivatives were obtained in up to 50% conversion and >99% ee.