ZnO nanoparticles as reusable heterogeneous catalyst for efficient one pot three component synthesis of imidazo-fused polyheterocycles. Issue 12 (23rd March 2016)

• Record Type: Journal Article
• Authors: Swami, Suman; Devi, Nisha; Agarwala, Arunava; Singh, Virender; Shrivastava, Rahul
• Is Part Of: Tetrahedron letters. Volume 57:Issue 12(2016)
• Page Start: 1346
• Page End: 1350
• Publication Date: 2016-03-23
• Subjects: Multicomponent reaction -- Nanoparticles -- Imidazo[1, 2-a]pyridine -- Pyrazole; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.02.045
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: An efficient, simple, environmentally benign synthetic protocol is developed for synthesis of biologically and medicinally relevant pyrazole coupled imidazo[1, 2- a ]pyridine derivatives via three component reaction of alkyl-4-formyl-1-phenyl-1 H -pyrazole-3-carboxylate, 2-aminopyridine and isocyanide in the presence of nano-crystalline ZnO in ethanol through one pot chemical operation. The present synthetic protocol provides several advantages like operational simplicity, short reaction time, reusable catalyst, and easy work-up procedure.