A fast and efficient method for the preparation of the 5-lipoxygenase inhibitor myxochelin A. Issue 12 (23rd March 2016)

• Record Type: Journal Article
• Authors: Schieferdecker, Sebastian; Nett, Markus
• Is Part Of: Tetrahedron letters. Volume 57:Issue 12(2016)
• Page Start: 1359
• Page End: 1360
• Publication Date: 2016-03-23
• Subjects: Myxochelin -- Anticancer -- 5-Lipoxygenase; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.02.047
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Previous studies revealed the natural product myxochelin A to possess potent antitumour activity at non-cytotoxic concentrations. While its antiinvasive properties are possibly due to an inhibition of matrix metalloproteinases, the antileukemic effects of myxochelin A could be traced to an inhibition of human 5-lipoxygenase. These findings make myxochelin A an interesting model compound for pharmacological investigations. Here, we present a concise synthetic route for the preparation of myxochelin A, which only involves three steps.