BDCA3+CLEC9A+ human dendritic cell function and development. (May 2015)

• Record Type: Journal Article
• Authors: van der Aa, Evelyn; van Montfoort, Nadine; Woltman, Andrea M.
• Is Part Of: Seminars in cell & developmental biology. Volume 41(2015)
• Page Start: 39
• Page End: 48
• Publication Date: 2015-05
• Subjects: APC antigen presenting cell -- Ag antigen -- CLEC9A C-type lectin 9A -- CCR7 C-C chemokine receptor 7 -- CADM1 cell adhesion molecule 1 -- XCL1 chemokine (C motif) ligand 1 -- CLA cutaneous lymphocyte antigen -- CTL cytotoxic T lymphocytes -- DAMP damage-associated molecular pattern -- DC dendritic cell -- F-actin filamentous actin -- HPC hematopoietic progenitor cells -- IRF interferon regulatory factor -- IFN interferon -- LPS lipopolysaccharide -- MHC class I major histocompatibility complex class I -- moDC monocyte-derived DC -- mDC myeloid dendritic cell -- Necl2 nectin-like molecule 2 -- PRR pattern recognition receptor -- PBMC peripheral blood mononuclear cells -- pDC plasmacytoid dendritic cell -- polyI:C polyinosine-polycytidylic acid -- TM thrombomodulin -- TLR3 Toll-like receptor 3 -- XCR1 XC chemokine receptor 1; Dendritic cell subset -- BDCA3 -- Cross-presentation -- IFNλ -- Human -- Immune regulation; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2014.05.016
• Languages: English
• ISSNs: 1084-9521

Abstract

Highlights: This review summarizes current knowledge on human BDCA3 + CLEC9A + dendritic cells (DC). An overview of the phenotypic characteristics of BDCA3 + CLEC9A + DC is presented. The role of BDCA3 + CLEC9A + DC specialized functions in the induction and regulation of immunity is discussed. Factors involved in the developmental pathway of BDCA3 + CLEC9A + DC are described. Suggestions to further assess the potential of BDCA3 + CLEC9A + DC as possible tool or target for immunotherapy are provided. Abstract: Dendritic cells (DC) are the most potent antigen presenting cells (APC). They comprise a family of different subsets and play an essential role in the induction and regulation of immune responses. Recently, gene expression profiling identified BDCA3 + CLEC9A + DC as a separate human DC subset. This subset was identified in blood, where they represent the smallest population of human DC, as well as in lymphoid and peripheral tissues. This review summarizes the phenotypic, functional and developmental characteristics of BDCA3 + CLEC9A + DC in relation to their mouse equivalents CD8α + DC and CD103 + DC and other human DC subsets. Apart from being potent antigen presenting cells, their specialized functional capacities compared to other human DC subsets, indicate that these BDCA3 + CLEC9A + DC are of major importance in the induction of anti-viral and anti-tumor immunity. Further characterization of their functional properties, developmental pathways and underlying molecular mechanisms may identify target molecules to fully exploit the immune modulatory function of BDCA3 + CLEC9A + DC and potential use of these cells in immunotherapy.