Fabrication and dual imaging properties of quantum dot/silica core-shell particles immobilized with gold nanoparticles. (19th September 2018)

• Record Type: Journal Article
• Authors: Li, Ting-ting; Inose, Tomoya; Oikawa, Takahiro; Tokunaga, Masayuki; Hatoyama, Keiichiro; Nakashima, Kouichi; Kamei, Takashi; Gonda, Kohsuke; Kobayashi, Yoshio
• Is Part Of: Materials technology. Volume 33:Number 11(2018)
• Page Start: 737
• Page End: 747
• Publication Date: 2018-09-19
• Subjects: Quantum dot -- gold -- silica-coating -- core-shell -- nanoparticle -- fluorescence imaging -- X-ray imaging; Materials -- Periodicals; Materials science -- Periodicals; Materials -- Technological innovations -- Periodicals; 620.1105
• DOI: 10.1080/10667857.2018.1502504
• Languages: English
• ISSNs: 1066-7857

Abstract

ABSTRACT: The present work proposes a preparation method for core-shell nanoparticles composed of quantum dots (QDs), SiO2, large Au nanoparticles (Au L ), and small Au nanoparticles (Au S ). The QDs were silica-coated with a sol-gel method using tetraethyl orthosilicate (QD/SiO2 ). Au L and Au S were fabricated by reducing Au 3+ ions with sodium citrate and tetrakis(hydroxymethyl)phosphonium chloride in water, respectively. Amino groups were introduced onto QD/SiO2 surface by using (3-aminopropyl)-triethoxysilane (QD/SiO2 /NH2 ). Both Au L and Au S were immobilized on QD/SiO2 /NH2 by successively reacting Au L and Au S with QD/SiO2 /NH2 (QD/SiO2 /NH2 /Au L /Au S ). Surface modification of QD/SiO2 /NH2 /Au L /Au S was performed by using polyethylene glycol (PEG) with a thiol group (QD/SiO2 /NH2 /Au L /Au S /PEG). The QD/SiO2 /NH2 /Au L /Au S /PEG colloid solution could be clearly imaged via its fluorescence. Its computed tomography (CT) value per unit concentration of Au (M) was 1.2 × 10 4 HU/M. The QD/SiO2 /NH2 /Au L /Au S /PEGs were circulated in a mouse through blood vessels, and some of them became trapped and accumulated in the liver and spleen. Graphical Abstract: