Human behavioral assessments in current research of Parkinson's disease. (September 2016)

• Record Type: Journal Article
• Authors: Asakawa, Tetsuya; Fang, Huan; Sugiyama, Kenji; Nozaki, Takao; Kobayashi, Susumu; Hong, Zhen; Suzuki, Katsuaki; Mori, Norio; Yang, Yilin; Hua, Fei; Ding, Guanghong; Wen, Guoqiang; Namba, Hiroki; Xia, Ying
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 68(2016)
• Page Start: 741
• Page End: 772
• Publication Date: 2016-09
• Subjects: 6MWT six-minute walking test -- 6-OHDA 6-hydroxydopamine -- 9HPT 9-hole peg test -- ACE Addenbrooke's cognitive examination -- ADLs activities of daily life -- AIMS abnormal involuntary movement scale -- ASI anxiety status inventory -- ASs autonomic symptoms -- BAI Beck anxiety inventory -- BBT box and block task -- BDI Beck depression inventory -- BESTest balance evaluation systems test -- BTA brief test of attention -- CES-D centre for epidemiologic studies depression scale -- CET cognitive effort test -- CGI impulse control symptoms -- CISI-PD clinical impression of severity index for Parkinson's disease -- COPM Canadian occupational performance measure -- COTNAB Chessington occupational therapy neurologic assessment battery -- COWAT controlled oral word association test -- CV computer-vision -- DA dopamine -- DBS deep brain stimulation -- DEX dysexecutive questionnaire -- DR delayed response -- DRS–2 Mattis dementia rating scale -- EDS Edinburgh depression scale -- EMG electromyography -- FAB frontal assessment battery -- FOG freezing of gait -- FOGQ freezing of gait questionnaire -- FRTf food reaching test -- FSS fatigue severity scale -- FTSTS five times sit-to-stand test -- FTT finger tapping test -- GAI geriatric anxiety inventory -- GDS geriatric depression scale -- GHQ general health questionnaire -- GRIMS Golombok rust inventory of marital state -- GPS global position system -- HADS hospital anxiety and depression scale -- HAMD Hamilton depression scale -- HARS Hamilton anxiety rating scale -- HDI Hamilton depression inventory -- HMS Hopkins medication schedule -- ICB impulse control behavior -- ICBSS impulse control behavior severity scale -- ICSs impulse control symptoms -- IGT Iowa gambling task -- IUS intolerance of uncertainty scale -- JTT Jebsen Taylor hand function test -- LARS Lille apathy rating scale -- LAPAQ LASA physical activity questionnaire -- LB Lewy body -- IMU inertial motion sensors -- LRRK leucine-rich repeat kinase 2 -- MADRS montgomery-asberg depression rating scale -- MaSCS metacognitions about symptom control scale -- MCQ metacognitions questionnaire -- MDS movement disorder society -- MFB median forebrain bundle -- MGT Morisky green test -- Mini-BEST mini-balance evaluation systems test -- MMSE mini mental state examination -- MOCAT Montreal cognitive assessment test -- MPTP 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine -- NART national adult reading test -- NDD neurodegenerative disorder -- NMSS non-motor symptoms scale -- NOR novel object recognition -- NPI neuropsychiatric inventory -- ODDA once-daily dopamine agonist -- OMS objectification, multi-purpose and simplification -- PANSS positive and negative syndrome scale -- PAS Parkinson anxiety scale -- PD Parkinson's disease -- PDNMG Parkinson's Disease Non-motor Group -- PDSS Parkinson's disease sleep scale -- PET Positron emission tomography -- PSWQ Penn State worry question -- QOL quality of life -- QUIP questionnaire for impulsive-compulsive disorders in Parkinson's disease -- rCBF regional cerebral blood flow -- RRS ruminative response scale -- SAS starkstein apathy scale -- SASES Simpson-Angus scale for extrapyramidal symptoms -- SDS Zung self-rating depression scale -- SIP stepping in place -- SNpc substantia nigra pars compacta -- SRAS Zung self-rated anxiety scale -- SUB subtraction test -- TRS Tremor rating score -- TTCT Torrance test of creative thinking -- UPDRS unified Parkinson's disease rating scale -- UWB ultra wide band -- VOSP visual object and space perception test -- VMC visuo-motor coordination -- WCST Wisconsin card sorting test -- WMS Wechsler memory scale; Behavioral assessments -- Fine motor -- Free-moving counting -- Food reaching motor -- Locomotion motor symptoms -- Non-motor symptoms -- Parkinsonian model -- Neuropsychological tasks; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2016.06.036
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: Assessments should include motor- and non-motor symptoms. Assessments covering Human patients were discussed. Bias should be avoided during the experimental design. Principles of OMS are important in the experimental design for Human behavioral assessments. Improving the assessments for non-motor symptoms in PD patients was emphasized. Abstract: Parkinson's disease (PD) is traditionally classified as a movement disorder because patients mainly complain about motor symptoms. Recently, non-motor symptoms of PD have been recognized by clinicians and scientists as early signs of PD, and they are detrimental factors in the quality of life in advanced PD patients. It is crucial to comprehensively understand the essence of behavioral assessments, from the simplest measurement of certain symptoms to complex neuropsychological tasks. We have recently reviewed behavioral assessments in PD research with animal models (Asakawa et al., 2016). As a companion volume, this article will systematically review the behavioral assessments of motor and non-motor PD symptoms of human patients in current research. The major aims of this article are: (1) promoting a comparative understanding of various behavioral assessments in terms of the principle and measuring indexes; (2) addressing the major strengths and weaknesses of these behavioral assessments for a better selection of tasks/tests in order to avoid biased conclusions due to inappropriate assessments; and (3) presenting new concepts regarding the development of wearable devices and mobile internet in future assessments. In conclusion we emphasize the importance of improving the assessments for non-motor symptoms because of their complex and unique mechanisms in human PD brains.