Penetration of an artificial arterial thromboembolism in a live animal using an intravascular therapeutic microrobot system. Issue 4 (April 2016)

• Record Type: Journal Article
• Authors: Jeong, Semi; Choi, Hyunchul; Go, Gwangjun; Lee, Cheong; Lim, Kyung Seob; Sim, Doo Sun; Jeong, Myung Ho; Ko, Seong Young; Park, Jong-Oh; Park, Sukho
• Is Part Of: Medical engineering & physics. Volume 38:Issue 4(2016:Apr.)
• Page Start: 403
• Page End: 410
• Publication Date: 2016-04
• Subjects: Microrobot -- Electromagnetic -- Drilling -- Helmholtz coil -- Saddle coil; Biomedical engineering -- Periodicals; Biomedical Engineering -- Periodicals; Physics -- Periodicals; Génie biomédical -- Périodiques; Biomedical engineering; Electronic journals; Periodicals; 610.28
• DOI: 10.1016/j.medengphy.2016.01.001
• Languages: English
• ISSNs: 1350-4533

Abstract

Highlights: We proposed the intravascular therapeutic microrobot system, which employs an EMA system and bi-plane X-ray devices. We demonstrated a stable locomotion of the microrobot and executed a penetration test of an artificial arterial thromboembolism in the aorta of a live animal. The average length of the artificial thrombus occlusion was about 18 mm and the microrobot could penetrate the occlusion for 40.2 s. Abstract: The biomedical applications of wireless robots are an active area of study. In addition to moving to a target lesion, wireless locomotive robots can deliver a therapeutic drug for a specific disease. Thus, they hold great potential as therapeutic devices in blood vessel diseases, such as thrombi and occlusions, and in other diseases, such as cancer and inflammation. During a percutaneous coronary intervention (PCI), surgeons wear a heavy shielding cloth. However, they cannot escape severe radiation exposure owing to unstable shielding. They may also suffer from joint pains because of the weight of the shielding cloth. In addition, the catheters in PCIs are controlled by the surgeon's hand. Thus, they lack steering ability. A new intravascular therapeutic system is needed to address these problems in conventional PCIs. We developed an intravascular therapeutic microrobot system (ITMS) using an electromagnetic actuation (EMA) system with bi-plane X-ray devices that can remotely control a robot in blood vessels. Using this proposed ITMS, we demonstrated the locomotion of the robot in abdominal and iliac arteries of a live pig by the master-slave method. After producing an arterial thromboembolism in a live pig in a partial iliac artery, the robot moved to the target lesion and penetrated by specific motions (twisting and hammering) of the robot using the proposed ITMS. The results reveal that the proposed ITMS can realize stable locomotion (alignment and propulsion) of a robot in abdominal and iliac arteries of a live pig. This can be considered the first preclinical trial of the treatment of an artificial arterial thromboembolism by penetration of a blood clot.