Mycobacterium sherrisii visceral disseminated infection in an African HIV-infected adolescent. (April 2016)

• Record Type: Journal Article
• Authors: Santoro, Francesco; Santoro, Giulia; Del Giudice, Annalisa; Perna, Rossella; Iannelli, Francesco; Spagnuolo, Maria Immacolata; Bruzzese, Eugenia; Lo Vecchio, Andrea
• Is Part Of: International journal of infectious diseases. Volume 45(2016:Apr.)
• Page Start: 43
• Page End: 45
• Publication Date: 2016-04
• Subjects: Mycobacterium sherrisii -- Non-tuberculous mycobacteria -- HIV -- Abscess -- Children -- gyrB; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2016.02.011
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: The diagnosis of Mycobacterium sherrisii infections requires sequencing of the 16S rDNA. The first M. sherrisii gyr B sequence is presented in this work. An antibiotic regimen comprising clindamycin, clarithromycin, and moxifloxacin was effective. Summary: A case of visceral disseminated infection by Mycobacterium sherrisii in an African HIV-infected adolescent with multiple abdominal abscesses is reported. Despite multiple drug resistance to first-line antibiotics in vitro, long-term treatment with clarithromycin, moxifloxacin, and clindamycin, together with appropriate antiretroviral treatment, resulted in clinical and radiological cure after 19 months of therapy and follow-up.