DAILY VARIABILITY OF ARTERIAL STIFFNESS INDEX IN RELATION TO TARGET ORGAN DAMAGE AND SEVERITY OF ARTERIAL HYPERTENSION. (June 2018)

• Record Type: Journal Article
• Authors: Merezhanova, A.; Tarlovskaya, E.; Mazalov, K.; Mazalova, M.; Kamardina, N.; Kozlova, N.; Makarova, L.; Seredneva, L.; Suvorov, A.; Mokeeva, E.
• Is Part Of: Journal of hypertension. Volume 36(2018)Supplement 1
• Publication Date: 2018-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000539491.80964.81
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: to study the daily variability of arterial stiffness, depending on the severity of damage to target organs and the stage of hypertension (AH). Design and method: 107 patients with AH aged from 30 to 65 years were examined, mean age was 53.4 ± 0.9 years. Depending on the stage of AH, patients are divided into 3 groups. In 1 group with stage I 7 patients 38.4 ± 2.7 years; second group included 59 patients, 52.6 ± 1.1 years, and 3 group with stage III HB included 38 patients, 57.2 ± 1.2 years. With the help of the 24-hour BP monitoring system, mean values of pulse pressure (PP), SBP, DBP, arterial stiffness index (ASI) and the variability of these indicators during the day. For the evaluation of target organ damage, the glomerular filtration rate (GFR), the intima-media common carotid artery index was evaluated by the color duplex scanning method; and the left ventricular myocardial mass index was determined by echocardiography. Results: When assessing the parameters of monitoring of BP as a function of the stage of AH, it was found that as the severity of the blood flow increases from stages I to III, SBP and PP, while the variability of SBP increased during the transition from II to III stage of AH, while the variability of PP increased during the transition from I to II and from I to III stages of AH. In the correlation analysis, an increase in the number of significant var. ASI with BPMD parameters depending on the severity of the AH flow. Thus, in patients with stage II AH, variability ASI was associated with the PP and ASI, and in patients with stage III AH variability ASI had significant correlation with SBP, PP, ASI, variability of SBP and PP. Conclusions: The daily variability ASI, determined by a non-invasive oscillometric method, increases with a high degree of reliability as the severity of AH increases, unlike other BPMD parameters, which changed less significantly. The daily variability ASI has a close relationship with the average daily PP and variability in PP in patients with stage II and stage II AH.