Global Burden of Chronic Kidney Disease in 2010: A Systematic Analysis of Population-based Data Worldwide. (June 2015)

• Record Type: Journal Article
• Authors: Mills, Katherine T.; Xu, Yu; Zhang, Weidong; Bundy, Joshua D.; Chen, Chung-Shiuan; Kelly, Tanika N.; He, Jiang; Chen, Jing
• Is Part Of: Journal of hypertension. Volume 33(2015)Supplement 2
• Publication Date: 2015-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000469729.05741.d8
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Background: Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. We estimated the global prevalence and absolute burden of CKD in 2010 by pooling data from population-based studies. Methods: We searched MEDLINE (January 1990 to June 2014), International Society of Nephrology Global Outreach Program funded projects, and bibliographies of retrieved articles. We included 40 studies that reported sex- and age-specific prevalence of CKD in representative population samples. Data was extracted independently and in duplicate. Results: The age-standardized global prevalence of CKD stages 1–5 in adults aged ≥20 years in 2010 was 10.3% in men (95% confidence interval 10.1, 10.5%) and 12.1% in women (11.8, 12.4%): 8.6% in men (8.4, 8.9%) and 9.6% in women (9.4, 9.8%) in high-income countries, and 10.6% in men (10.3, 10.9%) and 12.9% in women (12.5, 13.3%) in low- and middle-income countries. The total number of adults with CKD was 224.0 million (218.7, 229.3 million) in men and 278.3 million (272.1, 284.6 million) in women: 48.3 million (47.1, 49.5 million) in men and 61.8 million (60.6, 63.1 million) in women in high-income countries, and 175.7 million (170.6, 180.9 million) in men and 216.5 million (210.4, 222.6 million) in women in low- and middle-income countries. Conclusions: This study indicates that CKD is an important global-health challenge, especially in low- and middle-income countries. National and international efforts for prevention, detection, and treatment of CKD are needed to reduce its morbidities and mortalities worldwide.