PP.18.22: COMPARISON OF AORTIC PULSE WAVE VELOCITY WITH ROUTINE TESTS OF TARGET ORGAN DAMAGE EVALUATION BASED ON SEPHAR II STUDY DATA. (June 2015)

• Record Type: Journal Article
• Authors: Darabont, R.; Tautu, O.; Lighezan, R.; Deaconu, A.; Onciul, S.; Dragoescu, B.; Andrei, R.D.; Dorobantu, M.
• Is Part Of: Journal of hypertension. Volume 33(2015)Supplement 1
• Publication Date: 2015-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000468276.09343.7c
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Our objective was to assess the prevalence and the influence on risk category prediction of an emerging indicator of target organ damage (TOD) - the aortic pulse wave velocity (PWVao) in comparison with two routine parameters – microalbuminuria and left ventricular hypertrophy on electrocardiography (LVH-ECG), in hypertensive patients. Design and method: In order to evaluate the cardiovascular (CV) risk using the SCORE chart for high CV risk countries, we have selected 424 hypertensive of 40 to 65 years old from the representative sample of SEPHAR II national survey. Subclinical organ damage was assessed by: PWVao > 10m/s – evaluated by an oscillometric method (Arteriograph); microalbuminuria - defined by an urinary albumin to urinary creatinine ratio (UACR) of 30–300 mg/g; LVH-ECG - based on a Cornell product >/=2440ms. Binary logistic regression analysis using stepwise LR method was used to validate predictors of high/very high SCORE risk category. Results: Mean age was 51.46 ± 5.82y, with 51.95% males. Microalbuminuria, PWVao associated with increased arterial stiffness and LVH-ECG have been recorded in 5%, 4.8% and 27.8% of cases, respectively. There were no significant differences between hypertensive patients with PWVao >10m/s with or without UACR 30–300 mg/g {8 (6.9%) vs. 2 (1.7%); p = 0.052} and with or without LVH-ECG respectively {8 (6.9%) vs. 2 (1.7%); p = 0.052}. Based on SCORE risk stratification chart 45.5% of patients were classified as having a high and very high CV risk. After addition of PWVao >10m/s {OR 3.42; 95%CI (1.08–10.80)}, UACR 30–300 mg/g {OR 2.06; 95%CI (0.84–5.08)} and LVH-ECG {OR 5.09; 95%CI (1.02–25.29)} to SCORE prediction model 24.6% of the study sample subjects have been reclassified from the low/intermediate SCORE risk category to the high/very high SCORE risk category. Conclusions: At a cut-off of >10m/s for PWVao, arterial stiffness is more frequently encountered than microalbuminuria and LVH-ECG and it is independently contributing to CV risk stratification in hypertensive patients. Therefore, PWVao cannot be substituted by routine tests in populational studies or in clinical setting and has his own significance in TOD evaluation.