Antiplasmodial phloroglucinol derivatives from Syncarpia glomulifera. Issue 11 (1st June 2016)

• Record Type: Journal Article
• Authors: Su, Qingxi; Dalal, Seema; Goetz, Michael; Cassera, Maria B.; Kingston, David G.I.
• Is Part Of: Bioorganic & medicinal chemistry. Volume 24:Issue 11(2016)
• Page Start: 2544
• Page End: 2548
• Publication Date: 2016-06-01
• Subjects: WBAREJWYPAHVKF-UHFFFAOYSA-N -- TWGHLFMURTVYAB-UHFFFAOYSA-N -- QGJZLNKBHJESQX-KLSVAQHHSA-N -- PHFUCJXOLZAQNH-OTMOLZNZSA-N -- WCGUUGGRBIKTOS-GPOJBZKASA-N -- RGMMTOZHCJCZRW-UHFFFAOYSA-N; Antiplasmodial activity -- Phloroglucinol -- Syncarpia glomulifera (Myrtaceae); Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2016.04.020
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: Bioassay guided fractionation of a MeOH extract of the stem bark of Syncarpia glomulifera (Myrtaceae) led to the isolation of the two new phloroglucinol derivatives (±)-rhodomyrtosone F (1 ) and (±)-calliviminone C (2 ), the three known triterpenes, betulinic acid (3 ), ursolic acid-3-acetate (4 ), and ursolic acid (5 ), and 1-(2, 4, 6-trihydroxyphenyl)-1-hexanone (6 ). Compound1 exhibited strong antiplasmodial activity, while compounds2 –4 were moderately active and5 and6 were inactive in this assay. The structures of1 and2 were elucidated based on analyses of their mass spectrometric data, 1D and 2D NMR spectra, and comparison with related compounds.