Immunotherapy for opportunistic infections: Current status and future perspectives. Issue 8 (16th November 2016)

• Record Type: Journal Article
• Authors: Fuji, Shigeo; Löffler, Jürgen; Einsele, Hermann; Kapp, Markus
• Is Part Of: Virulence. Volume 7:Issue 8(2016)
• Page Start: 939
• Page End: 949
• Publication Date: 2016-11-16
• Subjects: adoptive immunotherapy -- aspergillus -- mold infection -- viral infection; Virulence (Microbiology) -- Periodicals; Bacterial diseases -- Periodicals; Molecular microbiology -- Periodicals; 579.05
• DOI: 10.1080/21505594.2016.1207038
• Languages: English
• ISSNs: 2150-5608

Abstract

ABSTRACT: The outcome after allogeneic haematopoietic stem cell transplantation (allo-HSCT) has significantly improved during the last decades. However, opportunistic infections such as viral and mold infections are still a major obstacle for cure. Within this field, adoptive T cell therapy against pathogens is a promising treatment approach. Recently, the techniques to develop T cell products including pathogen-specific T cells have been sophisticated and are now available in accordance to good manufacturing practice (GMP). Here, we aim to summarize current knowledge about adoptive T cell therapy against viral and mold infections.