Assessment of Detoxifying Markers for Florfenicol in Rainbow Trout Liver. Issue 4 (1st October 2016)

• Record Type: Journal Article
• Authors: Elia, Antonia Concetta; Pacini, Nicole; Fioravanti, Maria Letizia; Dörr, Ambrosius Josef Martin; Zaccaroni, Annalisa; Parmeggiani, Alba Maria; Gustinelli, Andrea; Mordenti, Oliviero; Abete, Maria Cesarina; Prearo, Marino
• Is Part Of: Journal of aquatic animal health. Volume 28:Issue 4(2016)
• Page Start: 258
• Page End: 265
• Publication Date: 2016-10-01
• Subjects: Aquatic animals -- Periodicals; Aquatic animals -- Diseases -- Periodicals; 571.917
• DOI: 10.1080/08997659.2016.1206637
• Languages: English
• ISSNs: 0899-7659

Abstract

Abstract: Florfenicol (FF) is employed in fish farms to contest or prevent bacterial infections. However, this pharmaceutical may produce reactive oxygen species that may cause biochemical changes in antibiotic-treated fish. The aim of this study was to evaluate the effect of FF on Rainbow Trout Oncorhynchus mykiss treated for 10 d with 7.5 and 15 mg/kg FF followed by a withdrawal period of 5 d. Superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, glyoxalase I and glyoxalase II, total glutathione, lactic dehydrogenase, and alkaline phosphatase were investigated in the livers of treated and untreated fish. A general impairment of antioxidant enzymes and metabolic indicators was measured in FF-treated Rainbow Trout. Onset of oxidative damage may have occurred during the antibiotic treatment as a consequence of the effect of FF toxicity at mainly the highest dose. Nevertheless, the rise in levels of total glutathione and glutathione S-transferase even after the withdrawal period may shield the antibiotic-mediated oxidative processes. Received December 22, 2015; accepted May 26, 2016 Published online October 28, 2016