Transdermal iontophoretic drug delivery: advances and challenges. (27th May 2016)

• Record Type: Journal Article
• Authors: Ita, Kevin
• Is Part Of: Journal of drug targeting. Volume 24:Number 5(2016)
• Page Start: 386
• Page End: 391
• Publication Date: 2016-05-27
• Subjects: Drug delivery -- iontophoresis -- percutaneous route -- skin -- sustainedrelease -- transdermal; Drug delivery systems -- Periodicals; Drug Delivery Systems; Vehicles; Drug Administration Routes; Drug Evaluation; 615.7
• DOI: 10.3109/1061186X.2015.1090442
• Languages: English
• ISSNs: 1061-186X

Abstract

Abstract: The stratum corneum continues to pose considerable impediment to transdermal drug delivery. One of the effective ways of circumventing this challenge is through the use of iontophoresis. Iontophoresis uses low-level current to drive charged compounds across the skin. This review discusses progress made in the field of iontophoretic transport of small and large molecules. The major obstacles are also touched upon and advances made in the last few decades described. A number of iontophoretic systems approved for clinical use by regulatory authorities is also discussed.