Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants. Issue 44 (4th November 2015)
- Record Type:
- Journal Article
- Title:
- Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants. Issue 44 (4th November 2015)
- Main Title:
- Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants
- Authors:
- Jameson, Victoria J.A.
Cochemé, Helena M.
Logan, Angela
Hanton, Lyall R.
Smith, Robin A.J.
Murphy, Michael P. - Abstract:
- Abstract: A series of mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker have been prepared. The synthesis of a series of mitochondria-targeted vitamin E derivatives with a range of alkyl linkers gave compounds of different hydrophobicities. This work will enable the dependence of antioxidant defence on hydrophobicity to be determined in vivo. Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 71:Issue 44(2015)
- Journal:
- Tetrahedron
- Issue:
- Volume 71:Issue 44(2015)
- Issue Display:
- Volume 71, Issue 44 (2015)
- Year:
- 2015
- Volume:
- 71
- Issue:
- 44
- Issue Sort Value:
- 2015-0071-0044-0000
- Page Start:
- 8444
- Page End:
- 8453
- Publication Date:
- 2015-11-04
- Subjects:
- Mitochondria -- Mitochondria-targeted antioxidant -- Lipid peroxidation -- Vitamin E -- MitoE
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2015.09.014 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 7336.xml