A systems pharmacology approach to decipher the mechanism of danggui-shaoyao-san decoction for the treatment of neurodegenerative diseases. (3rd February 2016)

• Record Type: Journal Article
• Authors: Luo, Yunxia; Wang, Qi; Zhang, Yongbin
• Is Part Of: Journal of ethnopharmacology. Volume 178(2016)
• Page Start: 66
• Page End: 81
• Publication Date: 2016-02-03
• Subjects: DSS danggui-shaoyao-san -- NDs neurodegenerative diseases -- TCM traditional Chinese medicine -- AD Alzheimer's disease -- PD Parkinson's disease -- HD Huntington's disease -- ALS amyotrophic lateral sclerosis -- AIA aspirin-intolerant asthma -- PRA Paeoniae Radix Alba -- ASR Angelica Sinensis Radix -- CR Chuanxiong Rhizoma -- P Poria -- AMR Atractylodis Macrocephalae Rhizoma -- AR Alismatis Rhizoma -- TCMSP the traditional Chinese medicine systems pharmacology database and analysis platform -- OB oral bioavailability -- DL drug-likeness -- CaCo2 Caco-2 permeability -- BBB blood-brain barrier -- HL half-life -- SVM support vector machine -- RF random forest -- ADME absorption, distribution, metabolism and excretion -- TDDSM Treating Different Diseases with the Same Method -- YBTZ YingBing TongZhi -- TPA 12-O-tetradecanoylphorbol-13-acetate -- ER Endoplasmic reticulum -- NDUFAB1 Acyl carrier protein, mitochondrial -- HSD11B2 Corticosteroid 11-beta-dehydrogenase isozyme 2 -- ADCY1 Adenylate cyclase type 1 -- NR3C1 Glucocorticoid receptor -- ADORA2A Adenosine receptor A2a -- ADORA1 Adenosine receptor A1 -- BCHE butyrylcholinesterase -- ACHE Acetylcholinesterase -- mGluR G protein–coupled glutamate receptors -- GRIN2B Glutamate receptor ionotropic, NMDA 2B -- GRM5 Metabotropic glutamate receptor 5 -- NDUFAB1 Acyl carrier protein, mitochondrial -- CACNA1D Voltage-dependent l-type calcium channel subunit alpha-1D -- CACNA1S Voltage-dependent l-type calcium channel subunit alpha-1S -- TNFRSF1A Tumor necrosis factor receptor superfamily member 1A -- MAPK14 Mitogen-activated protein kinase 14; kaempferol (PubChem CID: 5280863) -- Atractylenolide I (PubChem CID:5321018) -- Atractylenolide III (PubChem CID: 155948) -- α-Amyrin (PubChem CID: 73170) -- ligustilide (PubChem CID: 5319022) -- Z-ligustilide (PubChem CID: 529865) -- Ferulic acid (PubChem CID: 445858) -- Pachymic acid (PubChem CID: 5484385) -- Poricoic acid B (PubChem CID: 5471852) -- Poricoic acid C (PubChem CID: 16757534); Systems pharmacology -- Danggui-shaoyao-san -- TCM -- Neurodegenerative diseases; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2015.12.011
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Ethnopharmacological relevance: Neurodegenerative diseases (NDs) is a time-dependent course for a sequence of conditions that primarily impact the neurons in the human brain, ultimately, resulting in persistence and progressive degeneration and / or death of nerve cells and reduction of cognition and memory function. Currently, there are no therapeutic approaches to cure neurodegeneration, except certain medicines that temporarily alleviate symptoms, facilitating the improvement of a patients' quality of life. Danggui-shaoyao-san (DSS), as a famous Chinese herbal formula, has been widely used in the treatment of various illnesses, including neurodegenerative diseases. Although well-practiced in clinical medicine, the mechanisms involved in DSS for the treatment of neurodegenerative diseases remain elusive. Materials and methods: In the present study, a novel systems pharmacology approach was developed to decipher the potential mechanism between DSS and neurodegenerative disorders, implicated in oral bioavailability screening, drug-likeness assessment, target identification and network analysis. Results: Based on a comprehensive systems approach, active compounds of DSS, relevant potential targets and targets associated with diseases were predicted. Active compounds, targets and diseases were used to construct biological networks, such as, compound-target interactions and target-disease networks, to decipher the mechanisms of DSS to address NDs. Conclusions: Overall, a well-understood picture of DSS, hallmarked by multiple herbs-compounds-targets-pathway-cooperation networks for the treatment of NDs, was revealed. Notably, this systems pharmacology approach provided a novel in silico approach for the development paradigm of traditional Chinese medicine (TCM) and the generation of new strategies for the management of NDs. Graphical abstract: