Novel insights into how autophagy regulates tumor cell motility. Issue 9 (1st September 2016)

• Record Type: Journal Article
• Authors: Mowers, Erin E.; Sharifi, Marina N.; Macleod, Kay F.
• Is Part Of: Autophagy. Volume 12:Issue 9(2016)
• Page Start: 1679
• Page End: 1680
• Publication Date: 2016-09-01
• Subjects: autophagy -- cell motility -- focal adhesion -- metastasis -- paxillin -- SRC; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2016.1203487
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: Metastasis requires tumor cells to overcome a series of challenges to successfully travel to and colonize new microenvironments. As an adaptive (or maladaptive) response to stress, macroautophagy/autophagy has garnered increasing interest with respect to cancer metastasis, supported by clinical observations of increased autophagic flux in distant metastases relative to primary tumors. Recently, we identified a new role for autophagy in tumor cell motility through the turnover of focal adhesions, large multi-protein structures that link extracellular matrix-bound integrins to the cytoskeleton. The disassembly of focal adhesions at the cell rear is critical to forward movement and successful migration/invasion. We demonstrated that the focal adhesion protein PXN (paxillin), which serves as a crucial scaffolding and signal integrator, binds directly to LC3B through a conserved LC3-interacting region (LIR) motif to stimulate focal adhesion disassembly and metastasis and that this interaction is further promoted by oncogenic SRC.