MiR-210 and hypoxic microvesicles: Two critical components of hypoxia involved in the regulation of killer cells function. Issue 1 (28th September 2016)

• Record Type: Journal Article
• Authors: Noman, Muhammad Zaeem; Janji, Bassam; Berchem, Guy; Chouaib, Salem
• Is Part Of: Cancer letters. Volume 380:Issue 1(2016)
• Page Start: 257
• Page End: 262
• Publication Date: 2016-09-28
• Subjects: HIF hypoxia-inducible factor -- O2 oxygen -- miRNAs microRNAs -- miR-210 microRNA-210 -- HRM hypoxia regulated miRNAs -- MVs microvesicles -- EVs extracellular vesicles -- EXs exosomes -- HMVs hypoxic microvesicles -- TGF-β transforming growth factor-β -- CTL cytotoxic T lymphocyte -- NK natural killer cells; Hypoxia -- HIF -- Tumor microenvironment -- miR-210 -- MVs -- Immunosuppression and antitumor-immune response; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.10.026
• Languages: English
• ISSNs: 0304-3835

Abstract

Highlights: Hypoxia is a hallmark of all solid tumors favoring metastasis and poor prognosis. Hypoxia-induced miR-210 is a master regulator of hypoxic tumor response. We showed that miR-210 fine tunes the tumoral response to hypoxia. Exosomes and microvesicles released from hypoxic tumor regulate killer cell function. This review outlines how killer function depends on miR-210 and hypoxic microvesicles. Abstract: It has become clear that tumor stroma components are engaged in an active and complex molecular cross-talk that has serious implications for immunological recognition of tumor cells in shaping the microenvironment. Hypoxia which is a major component of tumor microenvironment influences the characteristics of neoplasia by favoring heterogeneity, invasiveness, metastatic potency and tumor progression. In this regard, an important mode of communication between carcinoma cells and immune cells may involve tumor-derived microvesicles, which are able to carry lipids, proteins, mRNAs and miRNAs. This review covers new evidence indicating that the efficacy of the cell-mediated cytotoxicity (CTLs and NK) may be dependent on hypoxia induced miRNA and microvesicles in the tumor microenvironment by inhibiting the efficacy of natural host anti-tumor immune response and improving the ability of tumors to avoid immunosurveillance. This emphasizes that hypoxic tumors actively develop additional mechanisms to suppress the sensing of the immunologic danger signals in order to survive and propagate without inciting anti-tumor immunity.