Facile synthesis of acacetin and its derivatives. Issue 15 (1st August 2016)

• Record Type: Journal Article
• Authors: Zhao, Yuan; Cai, Li; Sui, Qiang; Lin, Feng; Jiang, Wen; Chen, Jianli; Lu, Weigeng; Gao, Qi
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 15(2016)
• Page Start: 3577
• Page End: 3580
• Publication Date: 2016-08-01
• Subjects: Flavones -- Acacetin -- Synthesis -- Fries rearrangement -- Atrial fibrillation -- Catalysis; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.06.018
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Acacetin, a O -methylated bioflavonoid isolated from the traditional Chinese medicine Xuelianhua ( Saussurea tridactyla ), is a promising orally effective atrium-selective antiarrhythmic agent for the treatment of atrial fibrillation (AF). Here we describe an efficient two-component method for the synthesis of acacetin and its derivatives.