Antibacterial activities of fluorescent nano assembled triphenylamine phosphonium ionic liquids. Issue 15 (1st August 2016)

• Record Type: Journal Article
• Authors: Brunel, Frédéric; Lautard, Christelle; Garzino, Frédéric; Giorgio, Suzanne; Raimundo, Jean M.; Bolla, Jean M.; Camplo, Michel
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 15(2016)
• Page Start: 3770
• Page End: 3773
• Publication Date: 2016-08-01
• Subjects: ESKAPE Enterococcus faecium, Staphylococcus aureus, Klebsiella species, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species -- IL's ionic liquids -- MIC minimal inhibitory concentration -- TBAF tetrabutylamonium fluoride -- TEM transmission electronic microscopy -- TPA triphenylamine -- PIL's phosphonium ionic liquids; Triphenylamine -- Phosphonium ionic liquids -- Fluorescent probes -- Antimicrobial -- Staphylococcus aureus; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.05.055
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Staphylococcus aureus, a Gram positive coccal bacterium is a major cause of nosocomial infection. We report the synthesis of new triphenylamine phosphonium ionic liquids which are able to self-assemble into multiwall nanoassemblies and to reveal a strong bactericidal activity (MIC = 0.5 mg/L) for Gram positive bacteria (including resistant strains) comparable to that of standard antibiotics. Time kill, metabolism and fluorescence confocal microscopy studies show a quasi-instantaneously penetration of the nanoassemblies inside the bacteria resulting of a rapid blocking (30 min) of their proliferation. As confirmed by rezasurin reduction monitoring, these compounds strongly affect the bacterial metabolism and a Gram positive versus Gram negative selectivity is clearly observed. These fluorescent phosphonium ionic liquid might constitute a useful tool for both translocation studies and to tackle infectious diseases related to the field of implantology.