Protective effect of α-mangostin against iodixanol-induced apoptotic damage in LLC-PK1 cells. Issue 15 (1st August 2016)

• Record Type: Journal Article
• Authors: Lee, Dahae; Choi, Young Ok; Kim, Ki Hyun; Chin, Young-Won; Namgung, Hojin; Yamabe, Noriko; Jung, Kiwon
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 15(2016)
• Page Start: 3806
• Page End: 3809
• Publication Date: 2016-08-01
• Subjects: Contrast -- Alpha mangostin -- Iodixanol -- MAPK -- Caspase; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.05.031
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Radiographic contrast media facilitate the visibility of internal body structures, but its use to patients with lowered renal function needs to be careful because of severe side effect in kidney. The present study aims to evaluate potential protective effect and mechanism of Alpha mangostin (α-mangostin) against contrast-induced apoptotic damage in LLC-PK1 cells. As a result, α-mangostin in non-toxic concentrations improved the viability of the iodixanol-treated cells up to 90.42% against contrast-induced damage in LLC-PK1 cells. Iodixanol treatment increased the phosphorylation of p38, ERK and cleavage of caspase-3 in LLC-PK1 cells, which were significantly decreased by co-treatment with α-mangostin (2.5 and 5 μM). The protective effect of α-mangostin on contrast-induced apoptotic damage was mediated by the inhibition of MAPKs and caspase activation.