Alanine triazole iridium-catalyzed C–N bond formation through borrowing hydrogen strategy. Issue 41 (12th October 2016)

• Record Type: Journal Article
• Authors: Yu, Xiaoli; Zhao, Ranran; Wan, Huida; Yang, Yongchun; Wang, Dawei
• Is Part Of: Tetrahedron letters. Volume 57:Issue 41(2016)
• Page Start: 4588
• Page End: 4591
• Publication Date: 2016-10-12
• Subjects: Alanine -- Triazole -- Iridium -- C–N bond formation -- Borrowing hydrogen; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.08.093
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: An efficient synthesis of secondary amines has been described through alanine triazole iridium-catalyzed C–N bond formation of an aromatic amine and an alkyl amine by using the borrowing hydrogen strategy. In addition, it was observed that alanine triazole iridium is also an efficient catalyst to promote C–N bond formation of an aromatic amine and alcohols with good to excellent yields. Highlights: Borrowing hydrogen reaction of an aromatic amine and an alkyl amine. C–N bond formation of an aromatic amine and alcohols. Alanine triazole iridium-catalyzed secondary amines synthesis. Abstract: An efficient synthesis of secondary amines has been described through alanine triazole iridium-catalyzed C–N bond formation of an aromatic amine and an alkyl amine using the borrowing hydrogen strategy. In addition, it was observed that alanine triazole iridium is also an efficient catalyst to promote C–N bond formation of an aromatic amine and alcohols with good to excellent yields.