Fungal mediated kinetic resolution of racemic acetates to (R)-alcohols using Fusarium proliferatum. Issue 41 (12th October 2016)

• Record Type: Journal Article
• Authors: Jadhav, Dipesh D.; Patil, Harshal S.; Chaya, Patil S.; Thulasiram, Hirekodathakallu V.
• Is Part Of: Tetrahedron letters. Volume 57:Issue 41(2016)
• Page Start: 4563
• Page End: 4567
• Publication Date: 2016-10-12
• Subjects: Microorganism -- Biocatalysis -- Kinetic resolution -- (R)-Alcohol -- Acetate; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.08.084
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Kinetic resolution of racemic acetates to ( R )-alcohols using Fusarium proliferatum . One-pot two step biocatalyst mediated de-esterification/oxidation. Kinetic resolution of racemic acyclic and cyclic acetates with high ee (>95%). Abstract: Fungal mediated kinetic resolution of seven acyclic/aromatic acetates was achieved using Fusarium proliferatum to furnish ( R )-alcohols in high enantiomeric excess (>95%). The kinetic resolution was established as one-pot two-step de-esterification/oxidation biocatalytic process. Further, the preparative scale synthesis of ( R )-(+)-1-phenylethanol was accomplished through de-esterification/oxidation of (±)-1-phenylethyl acetate using the whole cell of F. proliferatum NCIM 1105.