Equal sensitivity of the new generation QuantiFERON-TB Gold plus in direct comparison with the previous test version QuantiFERON-TB Gold IT. (August 2016)

• Record Type: Journal Article
• Authors: Hoffmann, H.; Avsar, K.; Göres, R.; Mavi, S.-C.; Hofmann-Thiel, S.
• Is Part Of: Clinical microbiology and infection. Volume 22:Number 8(2016)
• Page Start: 701
• Page End: 703
• Publication Date: 2016-08
• Subjects: Interferon-γ release assay -- QuantiFERON-TB Gold in tube -- QuantiFERON-TB Gold plus -- Sensitivity -- Tuberculosis; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2016.05.006
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: QuantiFERON-TB Gold IT analyses interferon-γ release from CD4 + T cells after stimulation with specific tuberculosis (TB) antigens. Its sensitivity is approximately 80% for active TB. A new test generation (QFTGplus) also analyses the response of CD8 + T cells. We investigated both test generations in a direct head-to-head comparison in a German pulmonary hospital. Sensitivity rates for active TB were identical, no matter whether diagnosis was bacteriologically confirmed or not.