Chronic consumption of an inositol-enriched carob extract improves postprandial glycaemia and insulin sensitivity in healthy subjects: A randomized controlled trial. Issue 3 (June 2016)

• Record Type: Journal Article
• Authors: Bañuls, Celia; Rovira-Llopis, Susana; Falcón, Rosa; Veses, Silvia; Monzó, Nuria; Víctor, Víctor M.; Rocha, Milagros; Hernández-Mijares, Antonio
• Is Part Of: Clinical nutrition. Volume 35:Issue 3(2016:Jun.)
• Page Start: 600
• Page End: 607
• Publication Date: 2016-06
• Subjects: Carob pod extract -- Inositols -- Pinitol -- Continuous glucose monitoring system -- Healthy subjects -- LDL particle size; CGMS continuous glucose monitoring system -- HOMA-IR homeostasis model assessment of insulin resistance -- IEB inositol-enriched beverage -- SB sucrose-sweetened beverage; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2015.05.005
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Inositols are thought to be mediators of the insulin signalling pathway. We assessed the effects of inositols on glycaemic control in fasting and postprandial states and evaluated lipoprotein profile and LDL particle size in healthy population. Methods: A 12-week double-blind clinical trial was performed with forty healthy subjects administered either an inositol-enriched beverage (IEB) -containing 2.23 g of inositols in 250 ml- or a sucrose-sweetened beverage (SB) twice a day. Anthropometric measurements, fasting glucose levels, insulin and HOMA-IR index, lipoprotein profile and postprandial glucose concentrations (measured using the continuous glucose monitoring system (CGMS)) were recorded throughout the intervention period. Results: Following the 12-week trial subjects receiving the IEB exhibited a significant decrease in insulin, HOMA-IR and Apo B and an increase in LDL particle size, whereas the SB group showed increases in BMI and fasting glucose concentration. Analysis of postprandial glucose levels at breakfast, lunch and dinner revealed a mean reduction of glucose of ≈14% and a significant reduction in the area under the curve at 24 h after consumption of the IEB. Conclusions: Our results show that chronic IEB supplementation induces a significant improvement in carbohydrated metabolism parameters in healthy subjects.