Association between magnesium status, oxidative stress and inflammation in preeclampsia: A case–control study. Issue 6 (December 2015)

• Record Type: Journal Article
• Authors: de Sousa Rocha, Vivianne; Della Rosa, Fernanda Brunacci; Ruano, Rodrigo; Zugaib, Marcelo; Colli, Célia
• Is Part Of: Clinical nutrition. Volume 34:Issue 6(2015:Dec.)
• Page Start: 1166
• Page End: 1171
• Publication Date: 2015-12
• Subjects: Magnesium -- Preeclampsia -- Oxidative stress -- Inflammation; AUC area under the curve -- CAT catalase -- CI confidence interval -- CRP C-reactive protein -- D difference between magnesium intake and EAR -- EAR estimated average requirement -- FFQ food frequency questionnaire -- GSH-Px glutathione peroxidase -- Hb hemoglobin -- HPLC high performance liquid chromatography -- IL6 interleukin 6 -- MDA malondialdehyde -- NF nuclear factor -- OR odds ratio -- PCTL percentile -- RDA recommended dietary allowance -- ROC receiver operating characteristic -- ROS reactive oxygen species -- SDD standard deviation of D -- TBA thiobarbituric acid -- TNF-α tumor necrosis factor alpha; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2014.12.001
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Preeclampsia is responsible for more than one-third of all maternal deaths in Brazil. The objectives of the present study were to evaluate magnesium status and its association with oxidative stress and inflammation in preeclamptic women, and to identify the predictor variables of the disorder. Methods: The study population consisted of 36 women divided into preeclamptic ( n = 18) and control groups ( n = 18). The preeclamptic group included women (≥20 weeks of pregnancy) with arterial pressure ≥ 140/90 mmHg and proteinuria >0.3 g/24 h, while the control group comprised pregnant women with no clinical/obstetric complications. Magnesium intake was assessed via a food frequency questionnaire validated for pregnant women in Brazil. Plasma, erythrocyte and urinary magnesium levels were determined by flame atomic absorption spectroscopy, while oxidative stress and inflammatory markers were assessed using standard protocols. Logistic regression analysis was used to identify the predictors of preeclampsia. Results: Preeclamptic and control groups were similar with respect to magnesium intake and urinary excretion, while plasma and erythrocyte magnesium concentrations were higher in the former group. Plasma magnesium was positively correlated with catalase and glutathione peroxidase activities and with concentrations of interleukin-6 and tumor necrosis factor alpha. Regression analysis showed that plasma magnesium and urinary 8-isoprostane were associated with preeclampsia. Conclusion: Magnesium status appears to result from homeostatic imbalance and physiological alterations typical of preeclampsia. Increased plasma magnesium and decreased urinary 8-isoprostane were considered predictors of preeclampsia.