Current advances in the functional studies of fatty acids and fatty acid-derived lipids in C. elegans. Issue 3 (2nd July 2016)

• Record Type: Journal Article
• Authors: Ying, Lu; Zhu, Huanhu
• Is Part Of: Worm. Volume 5:Issue 3(2016)
• Publication Date: 2016-07-02
• Subjects: aging -- C. elegans -- fatty acid -- fatty acid-derived lipids -- reproductive process -- stress response; Caenorhabditis elegans -- Periodicals; 592.57
• DOI: 10.1080/21624054.2016.1184814
• Languages: English
• ISSNs: 2162-4046

Abstract

ABSTRACT: Fatty acids and fatty acid-derived lipids (FAs/FADLs) play essential roles in many living organisms, including contributions to membrane structure and signaling transduction. Aberrant metabolism of FAs/FADLs often causes diseases and health problems. However, the detailed mechanistic studies of specific FAs/FADLs in vivo are limited. C. elegans has been an effective model system for FA/ FADL studies due to its powerful genetics and conserved lipid biosynthetic pathways. The recently developed high-throughput analytic tools also enable sophisticated profiling of lipids molecules in C. elegans, which is critical for understanding their specific functions. Here we review a subset of current advances in FA/FADL functional studies in C. elegans .