Impact of two rounds of praziquantel mass drug administration on Schistosoma mansoni infection prevalence and intensity: a comparison between community wide treatment and school based treatment in western Kenya. Issue 7 (June 2016)

• Record Type: Journal Article
• Authors: Onkanga, Isaac O.; Mwinzi, Pauline N.M.; Muchiri, Geoffrey; Andiego, Kennedy; Omedo, Martin; Karanja, Diana M.S.; Wiegand, Ryan E.; Secor, W. Evan; Montgomery, Susan P.
• Is Part Of: International journal for parasitology. Volume 46:Issue 7(2016)
• Page Start: 439
• Page End: 445
• Publication Date: 2016-06
• Subjects: Schistosomiasis -- Schistosoma mansoni -- Mass drug administration -- Praziquantel -- School based treatment -- Community wide treatment -- Prevalence; Parasitology -- Periodicals; Parasitology -- Periodicals; Parasitologie -- Périodiques; Parasitology; Periodicals; Electronic journals; 571.999
• DOI: 10.1016/j.ijpara.2016.01.006
• Languages: English
• ISSNs: 0020-7519

Abstract

Graphical abstract: Highlights: Comparison of mass drug administration approaches for schistosomiasis was performed. The study presents results of a mid-term analysis of a 5 year study. School-based and community-wide distribution yielded a similar prevalence decrease. School-based distribution had a greater impact on intensity of infection. Abstract: This study compared the effectiveness of the community-wide treatment and school-based treatment approaches in the control of Schistosoma mansoni infections in villages with ⩾25% prevalence in western Kenya. Stool samples from first year students, 9–12 year olds and adults (20–55 years) were analyzed by the Kato–Katz technique for S. mansoni eggs. After two rounds of treatment, S. mansoni prevalence and intensity levels significantly declined in both treatment approaches. Prevalence comparisons between the two approaches did not show any significant differences following treatment. However, infection intensity levels in the 9–12 year old school-attending pupils were significantly higher in the community-wide treatment arm than in the school-based treatment arm. Nevertheless, significant reductions in S. mansoni infection prevalence and intensity levels were achieved among school-age children regardless of the treatment approach used.