Secreted microRNAs from tumor cells can suppress immune function. (2nd April 2016)

• Record Type: Journal Article
• Authors: Chen, Xi; Liang, Hongwei; Zen, Ke; Zhang, Chen-Yu
• Is Part Of: Oncoimmunology. Volume 5:Number 4(2016)
• Publication Date: 2016-04-02
• Subjects: microvesicle -- PTEN -- regulatory T cell -- secreted microRNA -- tumor immune escape; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.4161/2162402X.2014.982407
• Languages: English
• ISSNs: 2162-402X

Abstract

Abstract : Our recent study reported an interesting finding that tumor cells can actively manipulate host immune function to facilitate tumor immune escape through the secretion of microRNAs (miRNAs). As an extension of this finding, we showed that blockage of the function of tumor-secreted miRNAs represents an effective therapeutic approach for cancer treatment.