Non-redundant roles for Th17 and Th22 cells in multiple myeloma clinical correlates. (2nd April 2016)

• Record Type: Journal Article
• Authors: Di Lullo, Giulia; Marcatti, Magda; Protti, Maria Pia
• Is Part Of: Oncoimmunology. Volume 5:Number 4(2016)
• Publication Date: 2016-04-02
• Subjects: BM mesenchymal stromal cells -- BM microenvironment -- bone disease -- disease prognosis -- IL-13 -- IL-17 -- IL-22 -- multiple myeloma -- Th17 cells -- Th22 cells; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2015.1093278
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: We recently reported that in multiple myeloma increased Th22 cell frequencies correlate with poor prognosis. Here we show that within the same patients' cohort Th17 cells associate with bone disease and not with prognosis. Thus, we propose that Th22 and Th17 cells play non-redundant roles in multiple myeloma and constitute independent therapeutic targets.