Procarcinogenic regulatory T cells in microbial-induced colon cancer. (2nd April 2016)

• Record Type: Journal Article
• Authors: Geis, Abby L.; Housseau, Franck
• Is Part Of: Oncoimmunology. Volume 5:Number 4(2016)
• Publication Date: 2016-04-02
• Subjects: Carcinogenesis; Enterotoxigenic Bacteroides fragilis; IL-17; inflammation; Microbiome; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2015.1118601
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: Regulatory T cell (Treg) promote IL-17-mediated colon tumorigenesis in multiple intestinal neoplasia (Min) mice colonized with enterotoxigenic Bacteroides fragilis (ETBF). Although they retain their immunosuppressive function, mucosal Treg are instrumental to initiate ETBF-triggered IL-17 colitis by limiting the availability of IL-2 in the local microenvironment. However, the mechanisms that trigger the recruitment of the pro-carcinogenic Treg in ETBF-colonized colon remained to be elucidated.