Assessment of the Biocompatibility of the PLLA-PLCL Scaffold Obtained by Electrospinning. (2015)

• Record Type: Journal Article
• Authors: Oyama, Helena T.T.; Cortella, Lucas R.X.; Rosa, Isabela N.S.; Filho, Leonardo E.R.; Hui, Wang S.; Cestari, Ismar N.; Cestari, Idágene A.
• Is Part Of: Procedia engineering. Volume 110(2015)
• Page Start: 135
• Page End: 142
• Publication Date: 2015
• Subjects: polymer -- PLLA-PLCL -- electrospinning -- scaffold -- tissue engineering.; Engineering -- Congresses; Engineering -- Periodicals; Engineering; Conference proceedings; Periodicals; 620.005
• DOI: 10.1016/j.proeng.2015.07.021
• Languages: English
• ISSNs: 1877-7058

Abstract

Abstract: Electrospun membranes of poly (L-Lactide) / poly (L-lactide-co-caprolactone) blend were produced and evaluated by physical and mechanical tests to use as a scaffold for cell growth. The membranes were seeded with endothelial cells (HUVEC) and after culturing time it was visualized by confocal laser scanning microscopy and scanning electron microscopy. The results indicate that the process parameters were capable of producing PLLA-PLCL membranes presenting fibers with diameters in the nanometer range. The scaffolds supported cell attachment and growth, indicating the feasibility of producing scaffolds by electrospinning technique, which could be used in tissue engineering applications.