Combined Elastic and Shear Stress Solicitations for Topological Optimisation of Micro-CT Based Scaffolds. (2015)

• Record Type: Journal Article
• Authors: Almeida, Henrique A.; Bártolo, Paulo J.
• Is Part Of: Procedia engineering. Volume 110(2015)
• Page Start: 159
• Page End: 166
• Publication Date: 2015
• Subjects: Computational technologies -- Topological optimization -- Tissue engineering -- Scaffolds -- Micro-CT data.; Engineering -- Congresses; Engineering -- Periodicals; Engineering; Conference proceedings; Periodicals; 620.005
• DOI: 10.1016/j.proeng.2015.07.024
• Languages: English
• ISSNs: 1877-7058

Abstract

Abstract: Advanced additive manufacturing technologies, namely Biomanufacturing, are being used to fabricate scaffolds with controlled architecture for tissue engineering applications. These technologies combined with computer-aided design (CAD) enable to produce three-dimensional structures layer-by-layer in a multitude of biomaterials. Actual prediction of the effective mechanical properties of scaffolds produced by Biomanufacturing, is very important for tissue engineering applications. A novel computer based technique for scaffold design is topological optimisation. Topological optimisation is a form of "shape" optimisation, usually referred to as "layout" optimisation. The goal of topological optimisation is to find the best use of material for a body that is subjected to either a single load or a multiple load distribution. In this research work, a topological optimization strategy is presented to find out the best material use for a construct subject to either a single load or a multiple load distribution, maximising its mechanical behaviour under tensile and shear stress solicitations. The proposed topological optimization scheme enables the design of ideal topological architectures based on existing biologic Micro-CT data for the design of biomimetic scaffolds.