Processing and Characterization of 3D Dense Chitosan Pieces, for Orthopedic Applications, by Adding Plasticizers. (2015)

• Record Type: Journal Article
• Authors: Figueiredo, Lígia; Moura, Carla; Pinto, Luís F.V.; Ferreira, Frederico Castelo; Rodrigues, Alexandra
• Is Part Of: Procedia engineering. Volume 110(2015)
• Page Start: 175
• Page End: 182
• Publication Date: 2015
• Subjects: chitosan -- bioabsorbable implants -- plasticizers -- mechanical properties -- citotocicity; Engineering -- Congresses; Engineering -- Periodicals; Engineering; Conference proceedings; Periodicals; 620.005
• DOI: 10.1016/j.proeng.2015.06.182
• Languages: English
• ISSNs: 1877-7058

Abstract

Abstract: In this work, plasticizer agents were incorporated in a chitosan based formulation, as a strategy to improve the fragile structure of chitosan based-materials. Three different plasticizers: ethylene glycol, glycerol and sorbitol, were blended with chitosan to prepare 3D dense chitosan specimens. The properties of the obtained structures were assessed for mechanical, microstructural, physical and biocompatibility behavior. The results obtained revealed that from the different specimens prepared, the blend of chitosan with glycerol has superior mechanical properties and good biological behavior, making this chitosan based formulation a good candidate to improve robust chitosan structures for the construction of bioabsorbable orthopedic implants.