Cytokine therapy restores antitumor responses of NK cells rendered anergic in MHC I-deficient tumors. (2nd January 2016)

• Record Type: Journal Article
• Authors: Ardolino, Michele; Raulet, David H
• Is Part Of: Oncoimmunology. Volume 5:Number 1(2016)
• Publication Date: 2016-01-02
• Subjects: cancer immunotherapy -- cytokines -- NK cells; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2014.1002725
• Languages: English
• ISSNs: 2162-402X

Abstract

Abstract : Recent extraordinary advances in cancer immunotherapy rely primarily on marshaling T cell responses. Here we discuss how NK cell responses can be amplified. We find that MHC I-deficient tumors induce anergy of NK cells but that cytokine therapy restores NK cell activity and increases the survival of mice bearing MHC I-deficient tumors.