Evaluation of platelet reactivity using P2Y12 reaction units in acute coronary syndrome with essential thrombocythemia: A case report. Issue 6 (June 2015)

• Record Type: Journal Article
• Authors: Yoshida, Naofumi; Hiranuma, Noritoshi; Ninomaru, Taira; Nagamatsu, Yuichi; Tamada, Naoki; Miyoshi, Tatsuya; Sasaki, Yoshihiro; Kanda, Gaku; Kobayashi, Noriyasu; Fujii, Takashi
• Is Part Of: Journal of cardiology cases. Volume 11:Issue 6(2015:Jun.)
• Page Start: 178
• Page End: 180
• Publication Date: 2015-06
• Subjects: Essential thrombocythemia -- Acute coronary syndrome -- Dual anti-platelet therapy -- P2Y12 reaction unit; Cardiology -- Periodicals; Cardiovascular Diseases -- Case Reports; Cardiovascular Diseases -- Periodicals; Cardiology -- Case Reports; Cardiology -- Periodicals; Cardiology; Electronic journals; Periodicals; 616.12
• DOI: 10.1016/j.jccase.2015.03.007
• Languages: English
• ISSNs: 1878-5409

Abstract

Abstract: Essential thrombocythemia (ET) has been reported to cause acute coronary disease. However, the efficacy of anti-platelet therapy for ET is unclear since there are individual differences in the platelet function of ET patients. Here we report a case of a 62-year-old man with ET who was admitted to our hospital because of acute coronary syndrome. He underwent coronary angioplasty. Dual anti-platelet therapy with aspirin (81 mg/day) and clopidogrel (75 mg/day) was subsequently initiated. We evaluated platelet reactivity in P2Y12 reaction units, and subsequently determined anti-platelet drugs and corresponding doses. <Learning objective: Essential thrombocythemia (ET) is a myeloproliferative disorder that causes acute coronary disease. As there are individual differences in the platelet function of patients with ET, the efficacy of anti-platelet therapy for these patients varies. Evaluation of platelet reactivity using P2Y12 reaction units is useful in determining appropriate anti-platelet drugs and corresponding doses.>