Highly efficient and regioselective synthesis of spirooxindolo pyrrolizidines by reaction of isatin, proline and acrylonitrile/methyl acrylate in water. Issue 21 (25th May 2016)

• Record Type: Journal Article
• Authors: Tiwari, Keshri Nath; Pandurang, Taur Prakash; Pant, Suyash; Kumar, Rahul
• Is Part Of: Tetrahedron letters. Volume 57:Issue 21(2016)
• Page Start: 2286
• Page End: 2289
• Publication Date: 2016-05-25
• Subjects: Spirooxindole -- 1, 3-Dipolarcycloaddition -- Isatin -- Proline -- Acrylonitrile; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.04.047
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A simple, ecofriendly and regioselective three-component condensation of nonstabilzed azomethine ylides generated in situ from isatins andl -proline with acrylonitrile/methyl acrylate to give spirooxindolo pyrrolizidines has been realized. The reaction highlights the use of water as a reaction medium with good to excellent yields of products from readily available precursors.