Age-Related Changes in the Lateral Lipid Distribution in a Human Lens Described by Mass Spectrometry Imaging. Issue 3 (June 2015)

• Record Type: Journal Article
• Authors: Pol, Jaroslav; Faltyskova, Helena; Krasny, Lukas; Volný, Michael; Vlacil, Ondrej; Hajduch, Marian; Lemr, Karel; Havlicek, Vladimir
• Is Part Of: European journal of mass spectrometry. Volume 21:Issue 3(2015)
• Page Start: 297
• Page End: 303
• Publication Date: 2015-06
• Subjects: lens -- eye -- imaging -- mass spectrometry -- lipid distribution -- hydrolysis -- lateral; Mass spectrometry -- Periodicals; Mass Spectrometry; Mass spectrometry; Periodicals; Periodicals; 543.6505
• DOI: 10.1255/ejms.1350
• Languages: English
• ISSNs: 1469-0667

Abstract

The lateral lipid distribution in eye lenses of three human donors were studied by matrix-assisted laser desorption ionization imaging mass spectrometry using a high mass resolution. By using exact mass measurements this study shows the relationship between the aging process and the number of lipids detected as well as between aging and the abundance of products derived from sphingomyelins by hydrolysis. Variable lipid composition was also observed in the nuclear, barrier, or cortex regions of the lens samples. This is the first study that suggests the distribution of lysolipids as a potential biomarker panel for the aging of human lens tissue.