Prostate tumor specific peptide–peptoid hybrid prodrugs. Issue 14 (15th July 2015)

• Record Type: Journal Article
• Authors: Lee, Jiyoun; Huang, Wei; Broering, James M.; Barron, Annelise E.; Seo, Jiwon
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 14(2015)
• Page Start: 2849
• Page End: 2852
• Publication Date: 2015-07-15
• Subjects: Peptoids -- Anti-cancer -- Prostate cancer -- Antimicrobial peptides -- Peptidomimetics -- Prodrug; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.04.092
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Inspired by naturally occurring host defense peptides, cationic amphipathic peptoids provide a promising scaffold for anti-cancer therapeutics. Herein, we report a library of peptide–peptoid hybrid prodrugs that can be selectively activated by prostate cancer cells. We have identified several compounds demonstrating potent anti-cancer activity with good to moderate selectivity. We believe that these prodrugs can provide a useful design principle for next generation peptide–peptoid hybrid prodrugs.