4‐Dimethylaminopyridine‐Catalyzed Regioselective [3+2] Cycloaddition of Isatin‐Derived Morita−Baylis−Hillman Adducts with Azo Esters: A Simple Protocol to Access 3‐Spiropyrazole‐2‐oxindoles. Issue 16 (4th July 2018)

• Record Type: Journal Article
• Authors: Ren, Yue; Meng, Ling‐Guo; Peng, Tao; Zhu, Lijuan; Wang, Lei
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 16(2018)
• Page Start: 3176
• Page End: 3180
• Publication Date: 2018-07-04
• Subjects: DMAP -- catalyst -- cycloaddition -- azo esters -- 3-spiropyrazole-2-oxindoles; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800552
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An efficient and regioselective 4‐dimethylaminopyridine catalyzed [3+2] cycloaddition of isatin‐derived Morita−Baylis−Hillman adducts with azo esters was developed for the construction of 3‐spiropyrazole‐2‐oxindoles. This protocol generated the desired spiropyrazoles in good to excellent yields with good functional group compatibility under mild reaction conditions. Abstract :