Day-to-day variability of toxic events induced by organic compounds bound to size segregated atmospheric aerosol. (July 2015)

• Record Type: Journal Article
• Authors: Topinka, Jan; Rossner, Pavel; Milcová, Alena; Schmuczerová, Jana; Pěnčíková, Kateřina; Rossnerová, Andrea; Ambrož, Antonín; Štolcpartová, Jitka; Bendl, Jan; Hovorka, Jan; Machala, Miroslav
• Is Part Of: Environmental pollution. Volume 202(2015)
• Page Start: 135
• Page End: 145
• Publication Date: 2015-07
• Subjects: Air pollution -- Carcinogenic PAH -- Dioxin-like activity -- DNA adducts -- Oxidative damage -- Particulate matter; 8-oxodG 8-oxodeoxyguanosine -- dae aerodynamic diameter -- B[a]P benzo[a]pyrene -- B[b]F benzo[b]fluoranthene -- B[k]F benzo[k]fluoranthene -- B[a]A benz[a]anthracene -- BPDE benzo[a]pyrene-r-7, t-8-dihydrodiol-t-9, 10-epoxide[±] -- c-PAHs carcinogenic polycyclic aromatic hydrocarbons -- CHRY chrysene -- CT DNA calf-thymus DNA -- DRZ diagonal radioactive zone -- DB[al]P dibenzo[a, l]pyrene -- DB[ah]A dibenz[a, h]anthracene -- DCM dichlormethane -- 7, 12-DMBA 7, 12-dimethylbenz[a]anthracene -- DMSO dimethylsulfoxide -- EOM extractable organic matter -- HPLC high performance liquid chromatography -- I[cd]P indeno[1, 2, 3-c, d]pyrene -- PAH polycyclic aromatic hydrocarbons -- PM particulate matter -- PM10 particulate matter of aerodynamic diameter <10 μm -- TEQ toxic equivalency factor -- WHO World Health Organization; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2015.03.024
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: This study quantified the temporal variability of concentration of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs), genotoxicity, oxidative DNA damage and dioxin-like activity of the extractable organic matter (EOM) of atmospheric aerosol particles of aerodynamic diameter (dae, μm) coarse (1 &lt; dae &lt; 10), upper- (0.5 &lt; dae &lt; 1) and lower-accumulation (0.17 &lt; dae &lt; 0.5) and ultrafine (&lt;0.17) fractions. The upper accumulation fraction formed most of the aerosol mass for 22 of the 26 study days and contained ∼44% of total c-PAHs, while the ultrafine fraction contained only ∼11%. DNA adduct levels suggested a crucial contribution of c-PAHs bound to the upper accumulation fraction. The dioxin-like activity was also driven primarily by c-PAH concentrations. In contrast, oxidative DNA damage was not related to c-PAHs, as a negative correlation with c-PAHs was observed. These results suggest that genotoxicity and dioxin-like activity are the major toxic effects of organic compounds bound to size segregated aerosol, while oxidative DNA damage is not induced by EOM. Highlights: The day-to-day variability of the toxicity of organic extracts from PM was studied. Genotoxicity and dioxin-like activity are the main effects of compounds bound to PM. Upper accumulation mode exhibited highest genotoxicity and dioxin-like activity. Oxidative DNA damage is not induced by c-PAHs and other extract components. Abstract : The results suggest that genotoxicity and dioxin-like activity are the major toxic effects of organic compounds bound to size segregated aerosol, while oxidative damage is not induced.