MiSEA: microRNA set enrichment analysis. (August 2015)

• Record Type: Journal Article
• Authors: Çorapçıoğlu, M.Erdem; Oğul, Hasan
• Is Part Of: Bio systems. Volume 134(2015:Aug.)
• Page Start: 37
• Page End: 42
• Publication Date: 2015-08
• Subjects: microRNA expression profiling -- Gene set analysis -- Microarray analysis -- miRNA-Seq data analysis; Biological systems -- Periodicals; Biology -- Periodicals; Biology -- Periodicals; Evolution -- Periodicals; Biologie -- Périodiques; Évolution -- Périodiques; 570
• DOI: 10.1016/j.biosystems.2015.05.004
• Languages: English
• ISSNs: 0303-2647

Abstract

Abstract: We introduce a novel web-based tool, miSEA, for evaluating the enrichment of relevant microRNA sets from microarray and miRNA-Seq experiments on paired samples, e.g. control vs. treatment. In addition to a group of previously annotated microRNA sets embedded in the system, this tool enables users to import new microRNA sets obtained from their own research. miSEA allows users to select from a large variety of microRNA grouping categories, such as family classification, disease association, common regulation, and genome coordinates, based on their requirements. miSEA therefore provides a knowledge-driven representation scheme for microRNA experiments. The usability of this platform was discerned with a cancer type-classification task performed on a set of real microRNA expression profiling experiments. The miSEA web server is available athttp://www.baskent.edu.tr/∼hogul/misea