Resolution of racemic Vigabatrin using tartaric acid. Issue 17 (2nd September 2018)

• Record Type: Journal Article
• Authors: Karumanchi, Kishore; Kumar Natarajan, Senthil; Moturu, Krishna Murthy V. R.; Chavakula, Ramadas; Korupolu, Raghu Babu; Bonige, Kishore Babu
• Is Part Of: Synthetic communications. Volume 48:Issue 17(2018)
• Page Start: 2221
• Page End: 2225
• Publication Date: 2018-09-02
• Subjects: (R)-vigabatrin -- (S)-vigabatrin -- resolution -- vigabatrin-d-tartarate -- vigabatrin-l-tartarate; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2018.1489967
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: An efficient and simple resolution methodology for the preparation of ( S )- and ( R )-Vigabatrin has been developed. In addition, a method of preparation for the novel compounds Vigabatrin-l -tartarate and Vigabatrin-d -tartarate is also described. The title compounds have been synthesized via resolution of Vigabatrin using commercially availablel -(+)- andd -(−)-tartaric acids respectively. Graphical Abstract: