A class of Covariate-Adjusted Response-Adaptive Allocation Designs for Multitreatment Binary Response Trials. Issue 5 (3rd September 2018)

• Record Type: Journal Article
• Authors: Biswas, Atanu; Bhattacharya, Rahul
• Is Part Of: Journal of biopharmaceutical statistics. Volume 28:Issue 5(2018)
• Page Start: 809
• Page End: 823
• Publication Date: 2018-09-03
• Subjects: Covariate-adjusted allocation -- Ethics -- Response-adaptive design; Pharmacy -- Statistical methods -- Periodicals; Drugs -- Testing -- Statistical methods -- Periodicals; Biometry -- Periodicals; Biopharmaceutics -- Periodicals; Pharmacokinetics -- Periodicals; 615.19
• DOI: 10.1080/10543406.2018.1485683
• Languages: English
• ISSNs: 1054-3406

Abstract

ABSTRACT: A class of covariate-adjusted response-adaptive randomization procedures is developed for binary treatment outcomes in a phase III clinical trial set up involving multiple treatments. The target allocation is developed by combining the ethical aspects with statistical precision under the existence of treatment covariate interaction. Relevant measures of the performance for the proposed allocation designs are studied and compared.