The effect of bilateral low-frequency rTMS over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor and serotonin in patients with generalized anxiety disorder. (25th September 2018)

• Record Type: Journal Article
• Authors: Lu, Rulan; Zhang, Chengliang; Liu, Yanyan; Wang, Linxiao; Chen, Xia; Zhou, Xianju
• Is Part Of: Neuroscience letters. Volume 684(2018)
• Page Start: 67
• Page End: 71
• Publication Date: 2018-09-25
• Subjects: Generalized anxiety disorder -- Repetitive transcranial magnetic stimulation -- Brain-derived neurotropic factor -- Serotonin; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2018.07.008
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Bilateral low-frequency rTMS over DLPFC alleviates generalized anxiety disorder. Bilateral low-frequency rTMS over DLPFC enhances serum levels of BDNF and 5-HT. Increase of serum BDNF level is associated with Increase of serum 5-HT level. Decrease of HARS score is associated with increase of serum BDNF and 5-HT level. Abstract: To investigate the effect of bilateral low-frequency repetitive transcranial magnetic stimulation (rTMS) over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor (BDNF) and serotonin (5-HT) in patients with generalized anxiety disorders (GAD). As compared with before treatment, the HARS score in patients markedly decreased after treatment, and the levels of serum BDNF and 5-HT were significantly higher. Pearson correlation analysis revealed that the increase in the level of serum 5-HT was positively associated with the increase of the level of serum BDNF, and the change of anxiety score was negatively associated with the change of the level of serum BDNF and 5-HT. The results suggested that alleviation of GAD by bilateral low-frequency rTMS may be involved in the increase of the level of BDNF and the release of 5-HT in the brain.