A single preovulatory administration of ulipristal acetate affects the decidualization process of the human endometrium during the receptive period of the menstrual cycle. (15th November 2018)

• Record Type: Journal Article
• Authors: Lira-Albarrán, Saúl; Durand, Marta; Barrera, David; Vega, Claudia; Becerra, Rocio García; Díaz, Lorenza; García-Quiroz, Janice; Rangel, Claudia; Larrea, Fernando
• Is Part Of: Molecular and cellular endocrinology. Volume 476(2018)
• Page Start: 70
• Page End: 78
• Publication Date: 2018-11-15
• Subjects: Ulipristal acetate -- Endometrium -- Decidualization -- Gene transcription -- Emergency contraception; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2018.04.010
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: In order to get further information on the effects of ulipristal acetate (UPA) upon the process of decidualization of endometrium, a functional analysis of the differentially expressed genes in endometrium (DEG) from UPA treated- versus control-cycles of normal ovulatory women was performed. A list of 1183 endometrial DEG, from a previously published study by our group, was submitted to gene ontology, gene enrichment and ingenuity pathway analyses (IPA). This functional analysis showed that decidualization was a biological process overrepresented. Gene set enrichment analysis identified LIF, PRL, IL15 and STAT3 among the most down-regulated genes within the JAK STAT canonical pathway. IPA showed that decidualization of uterus was a bio-function predicted as inhibited by UPA. The results demonstrated that this selective progesterone receptor modulator, when administered during the periovulatory phase of the menstrual cycle, may affect the molecular mechanisms leading to endometrial decidualization in response to progesterone during the period of maximum embryo receptivity. Highlights: The periovulatory administration of UPA changes endometrial gene expression during the luteal phase of the cycle. Molecular activity prediction analysis indicated decidualization of uterus as inhibited by UPA. The results may explain the longer efficacy of UPA as an emergency contraceptive.