Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target. (3rd August 2018)

• Record Type: Journal Article
• Authors: Noman, Muhammad Zaeem; Paggetti, Jerome; Moussay, Etienne; Berchem, Guy; Janji, Bassam
• Is Part Of: Oncoimmunology. Volume 7:Number 8(2018)
• Publication Date: 2018-08-03
• Subjects: autophagy -- Beclin1 -- cancer immunotherapy -- CCL5 cytokine -- Immune infiltration -- immunotherapy -- melanoma -- natural killer cells; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2018.1452583
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: Natural Killer (NK) cell-based cancer immunotherapies were often disappointing in the clinic mostly due to insufficient NK cell infiltration into tumors. We found that targeting autophagy induced a massive infiltration of NK cells into melanoma tumors. These findings highlight autophagy inhibition as a cutting-edge approach to fully exploit the anti-tumor properties of NK cells in a wide variety of cancer patients.